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This causes a lot of heat generation and energy loss within the actuators.

This infectious disease results in Leprosy reactions that cause irreversible nerve damage and disabilities. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997) Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. In: Proceedings of the ACM/IEEE Conference on Supercomputing (SC06), Nov 11–17, Florida. Chemotherapy of leprosy for control programs- report of WHO study (2004). In this paper, we advanced two kinds of cellular genetic algorithms inspired by the density dependence scheme in ecological system to solving dynamic optimization problems.

Adhinarayanan, Maheswarapu Sydulu "Particle Swarm Optimisation for Economic Dispatch with Cubic Fuel Cost Function", TENCON 2006, IEEE region conference. Acyl Co A Synthetase is an enzyme that participates in fatty acid biosynthesis. The performance of proposed cellular genetic algorithms is examined under three dynamic optimization problems with different change severities.

Most of the genes are involved in biosynthetic and metabolic pathways, so the product of these genes can be aimed for the novel drug target. Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Moreover, in the second proposed rule, the competition scheme of the best individuals within the neighborhoods of one individual is also introduced.

Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot.

Therefore identification of the novel drug target and potent drug can be helpful in better prevention of the disease. Alter et.al, (2008) Leprosy as a genetic model for susceptibility to common infectious disease, Hum Genet 2. (1999)Health Policy and Planning; 14(2): 89-102, Oxford University Press.

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