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No strong evidence shows that any treatment other than surgery is effective.

Experts usually recommend surgery only in long-term cases in which the disease is stabilized and the deformity prevents intercourse.

The inner-surface membrane of the chamber is a sheath of elastic fibers.

A connecting tissue, called a septum, runs along the center of the chamber and attaches at the top and bottom.

The damaged area might heal slowly or abnormally for two reasons: repeated trauma and a minimal amount of blood-flow in the sheath-like fibers.

The plaque develops on the upper or lower side of the penis in layers containing erectile tissue.Radiation therapy, in which high-energy rays are aimed at the plaque, also has been used.Like some of the chemical treatments, radiation appears to reduce pain, yet it has no effect on the plaque itself and can cause unwelcome side effects.Men with Peyronie's disease usually seek medical attention because of painful erections and difficulty with intercourse.Since the cause of the disease and its development are not well understood, doctors treat the disease empirically; that is, they prescribe and continue methods that seem to help.

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